San Francisco 49ers vs Philadelphia Eagles Predictions, Picks, Odds, and Betting Preview | NFL Week 2 – September 19, 2021

Two teams that had success in the first week of the 2021 NFL season will collide this coming Sunday, as the San Francisco 49ers play the Philadelphia Eagles on the road. Check out our preview of this game below.

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Betting Preview for the San Francisco 49ers vs Philadelphia Eagles Regular Season Week 2 Game on September 19, 2021

Where: Lincoln Financial Field, Philadelphia

When: Sunday, September 19, 2021, 1:00 PM ET

Line: San Francisco 49ers (-3.5) vs Philadelphia Eagles (+3.5) – view all 2021 NFL lines

TV Broadcast: FOX

Betting on the San Francisco 49ers (-3.5)

Regular Season Record: 1-0

The 49ers managed to avoid an embarrassing meltdown in Week 1’s 41-33 road win over the Detroit Lions. The Niners were in total control for most of the game but got outscored 16-3 in the fourth quarter that led to Detroit managing to backdoor cover. Nevertheless, San Francisco got the win in the bag and will have some lessons to learn ahead of the showdown with the Eagles. Jimmy Garoppolo came up big in the pocket with 314 passing yards and a touchdown on 17/25 completions. He will still be looking over his shoulder with the threat of rookie Trey Lance taking over his starting gig, but that’s a good problem for now for San Francisco. The 49ers will not have running back Raheem Mostert for weeks after he suffered an injury in Week 1, though the backfield still has Elijah Mitchell and Trey Sermon. San Fransisco’s defense will look to rebound after letting up in the Detroit game. The team’s stop unit is so much better than what it showed during that forgettable fourth quarter against the Lions.

The over is 4-0 in the 49ers’ last four games after a win.

Betting on the Philadelphia Eagles (+3.5)

Regular Season Record: 1-0

The Eagles got off to an explosive start, and it’s because of the amazing job of the team on both ends of the field in a 32-6 road win over the Atlanta Falcons in Week 1. Jalen Hurts erased doubts once again on whether he can truly carry the Eagles’ offense by throwing for 264 yards and three touchdowns without an interception on 27/35 completions. Rookie wideout DeVonta Smith did not waste time showing off, as he led Philly with 71 receiving yards and a touchdown. Jalen Reagor also looked reenergized after posting 49 receiving yards and a TD, while catching all six targets. Including Hurts’ mobility and Miles Sanders’ versatility, this Philly offense can be more than a handful for San Francisco’s defense that could be without star linebacker Dre Greenlaw. Speaking of which, watch out for Javon Hargrave to be a force on the defensive front for the Eagles. He had two of Philly’s three sacks in Week 1

The Eagles are 5-0 against the spread in their last five games as the underdog at home.

Writer’s Prediction

The 49ers win, 27-20.

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