San Francisco 49ers vs Seattle Seahawks Predictions, Picks, Odds, and Betting Preview | Week 15 – December 15, 2022

The San Francisco 49ers beat the Seattle Seahawks back in Week 2, 27-7. The two teams meet again to kick off Week 15 of the 2022 NFL regular season. Will they beat the Seahawks again on Thursday? Or will the Seahawks pull off a huge win at home? Check out our preview of this 49ers vs Seahawks game in Week 15 of the 2022 NFL regular season.

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Betting Preview for the San Francisco 49ers vs Seattle Seahawks Week 15 Game on December 15, 2022

Where: Lumen Field, Seattle, Washington

When: Thursday, December 15, 2022, 8:15 PM ET

Line: San Francisco 49ers (-3.5) vs Seattle Seahawks (+3.5) – view all 2022 NFL lines

TV Broadcast: Prime Video

Betting on the San Francisco 49ers (-3.5)

Regular Season Record: 9-4

The 49ers still look like a legitimate Super Bowl contender even though they won’t be having Jimmy Garoppolo the rest of the way this season. Brock Purdy appears to be capable of handling the starting QB gig, and he showed that when he threw for 185 yards and two touchdowns without an interception in the Niners’ 35-7 destruction of the Tampa Bay Buccaneers at home last Sunday. The 49ers’ offense remains lethal and that should remain through whether Deebo Samuel (ankle) will be out in Week 15 or not. Their defense is also just as dangerous. The Seahawks coud be in trouble this time around – again

The Niners are 6-0 against the spread in their last six games against NFC West division teams.

Betting on the Seattle Seahawks (+3.5)

Regular Season Record: 7-6

The Seahawks are struggling for consistency of late, as they have gone just 2-3 straight-up in their last five games. They are coming off a 30-24 home loss to the Carolina Panthers at home in Week 14. It’s not about to get easier for them with the 49ers coming right up. That said, they can draw confidence from the fact that they are still punching above their weight overall this season. Seattle was not supposed to be jockeying for positioning in the playoffs this deep in the regular season, but with the surprising play of Geno Smith, the Seahawks continue to be a playoff contender in the NFC.

Also remember that the Seahawks are 8-2-1 against the spread in their last 11 games as a home team when up against San Francisco.

Writer’s Prediction

The 49ers win, 24-21.

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