San Francisco 49ers vs Tennessee Titans Predictions, Picks, Odds, and Betting Preview | NFL Week 16 – December 23, 2021

The San Francisco 49ers and the Tennessee Titans meet for the first time this season. Will the 49ers shine on Monday at Soldier Field? Or will the Titans break out of their slump and score a much-needed victory? Check out our preview of this 49ers-Titans Week 15 game.

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Betting Preview for the San Francisco 49ers vs Tennessee Titans Regular Season Week 16 Game on December 23, 2021

Where: Nissan Stadium, Nashville

When: Thursday, December 23, 2021, 8:20 PM ET

Line: San Francisco 49ers (-3.5) vs Tennessee Titans (+3.5) – view all 2021 NFL lines

TV Broadcast: NFLN

Betting on the San Francisco 49ers (-3.5)

Regular Season Record: 8-6

The Niners are somewhat silently putting together quite a hot stretch, having won five of their last six games. That includes their 31-13 home win over the Atlanta Falcons in Week 15, a week after going to Ohio and beating the Cincinnati Bengals there, 26-23. Jimmy Garoppolo is helping his own case as to why the Niners should stick to him despite the team taking a quarterback in the last NFL Draft. Garoppolo passed for 235 yards and a touchdown and without an interception on 18/23 completions. Even though San Francisco missed the services of running back Elijack Mitchell (concussion) in the Falcons game, the 49ers rushed for 162 yards and three touchdowns on 32 carries, thanks to Jeff Wilson Jr., who stepped up and led his team with 110 rushing yards and a touchdown on 21 carries. With how the Niners have been playing of late, they clearly have a shot at undressing Tennessee’s defense that had just been embarrassed by the Pittsburgh Steelers.

The 49ers are 5-1 against the spread in their last six games overall.

Betting on the Tennessee Titans (+3.5)

Regular Season Record: 9-5

The Titans took a huge stumble in Week 15, as they lost to the Pittsburgh Steelers on the road last Sunday. Turnovers hurt Tennessee badly in that game, as they gave the ball away a total of four times, three via fumbles. Not having running back Derrick Henry has certainly impacted the Titans, but D’Onta Foreman showed against the Steelers that he can be relied upon as the team’s top option on the ground by rushing for 108 yards on 22 carries. Meanwhile, the Titans’ passing attack is hoping that Julio Jones’ hamstring injury that forced him to exit the Steelers game is not serious enough to keep him out of Week 16’s meeting with the Niners. With a banged-up offensive unit, the Titans will have to rely more on their defense. The Titans recorded three sacks against the Steelers but were not able to force a turnover. Perhaps they can get one in Week 16 against the Niners, who walked into Week 15 ranked 20th in the league with a -0.2 turnover margin per contest.

The Titans are 4-2 against the spread in their last six games at home.

Writer’s Prediction

The 49ers win, 23-20.

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