Indianapolis Colts vs Denver Broncos Predictions, Picks, Odds, and Betting Preview | NFL Week 5 – October 6, 2022

After a stunning upset win over the Kansas City Chiefs in Week 3, the Indianapolis Colts came down to Earth hard in Week 4’s 24-17 home loss to the Tennessee Titans. There will be plenty of adjustments the Colts have to make if they are to avoid falling way beyond the race to the top of the AFC South division. Meanwhile, the Denver Broncos just became the first victim of the Las Vegas Raiders after suffering a 32-23 road loss to Derek Carr and company Sunday. Will the Colts get back into the win column in Week 5? Or will the Broncos secure their third win of the season?

Check out our preview of this Colts vs Broncos game in Week 5 of the 2022 NFL regular season.

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Betting Preview for the Indianapolis Colts vs Denver Broncos Week 5 Game on October 6, 2022

Where: Empower Field at Mile High, Denver, Colorado

When: Thursday, October 6, 2022, 8:15 PM ET

Line: Indianapolis Colts (+3.0) vs Denver Broncos (-3.0) – view all 2022 NFL lines

TV Broadcast: Prime Video

Betting on the Indianapolis Colts (+3.0)

Regular Season Record: 1-2-1

It’s still not too late for the Colts, but it is starting to get out of hand it seems. Matt Ryan hasn’t been triggering the success the Colts expected when they acquired him in the offseason, but they will have to rely on him more, especially if running back Jonathan Taylor can’t give it a go this Thursday. Taylor had an ankle issue that forced him out of the Titans game and with the Colts on a short week, they might have to play it safe and rest the star tailback. If that will be the case, Ryan and wideout Michael Pittman Jr. will have to step it up between themselves after the latter only had three catches on six targets for a mere 31 yards in Week 4.

The Colts are 5-1 against the spread in their last 6 games after a loss.

Betting on the Denver Broncos (-3.0)

Regular Season Record: 2-2

Although they lost to the Raiders, the Broncos at least scored more than 16 points for the first time this season. That’s a step in the right direction for Denver, though, the team might have a harder time picking up yards on the ground with running back Javonte Williams hurt. Williams was not able to finish the Raiders game because of what is feared to be a serious knee injury. The likelihood of him missing Thursday’s game is high at the moment, which would also mean Melvin Gordon is about to get a big uptick in his usage. Gordon is having ball security issues, but the Broncos will have to ride it out with him and hope he’ll get better soon in that area.

The Broncos are 11-4 against the spread in their last 15 Thursday games.

Writer’s Prediction

The Broncos win, 24-20.

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