Indianapolis Colts vs Arizona Cardinals Predictions, Picks, Odds, and Betting Preview | NFL Week 16 – December 25, 2021

The Indianapolis Colts continue their rise in the AFC South with another win in Week 15. But up ahead for them is a showdown against the angry Arizona Cardinals, who are looking to break out of a slump. Check out our preview below of this Week 16 matchup between the Colts and the Cardinals down in Glendale.

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Betting Preview for the Indianapolis Colts vs Arizona Cardinals Regular Season Week 16 Game on December 25, 2021

Where: State Farm Stadium, Glendale

When: Saturday, December 25, 2021, 8:15 PM ET

Line: Indianapolis Colts (+1.5) vs Arizona Cardinals (-1.5) – view all 2021 NFL lines

TV Broadcast: NFLN

Betting on the Indianapolis Colts (+1.5)

Regular Season Record: 8-6

What a luxury it’s been for the Colts to have running back Jonathan Taylor in their fold. Taylor took off for 170 rushing yards and a touchdown on 29 carries in Indianapolis’ 27-17 home win over the New England Patriots in Week 15. The Colts are now 5-1 straight up in their last six games. Stopping the Patriots must have also given Indianapolis a tremendous confidence boost, as it basically erased a few lingering doubts on the legitimacy of their current form following a 31-0 win over the going-nowhere Houston Texans on the road in Week 13. Taylor and the Colts also seem to be catching Arizona at a great time, as the Cardinals are struggling at the moment. It’s also a good sign for Taylor’s chances to wreak havoc again that the Cardinals got smashed on the ground by the Detroit Lions last Sunday for 126 rushing yards. The Colts’ defense looks ready to take on Kyler Murray as well after recording two interceptions and a sack in the win over the Patriots.

The Colts are 7-3 against the spread in their last 10 games overall.

Betting on the Arizona Cardinals (-1.5)

Regular Season Record: 10-4

What is wrong with the Cardinals? They are 0-2 in their last two games and 3-4 in their last seven. It’s certainly worrisome for Arizona fans that the Cards had just lost to the worst team in the NFL. The Cardinals couldn’t get much going in their 30-12 road loss to the Lions. Murray passed for 257 yards and a touchdown but had an interception and connected on only 23 of 41 passes. At the same time, it’s not easy to just write off the Cardinals, especially with the depth of the talent they have on offense, Sure, DeAndre Hopkins is on the injured reserve, but a receiving corps composed of the likes of Rondale Moore, Christian Kirk, AJ Green, and Zach Ertz remains deadly for opposing teams. The backfield duo of James Conner and a healthy Chase Edmonds can get things done on any given Sunday.

The Cardinals, who were averaging 28.2 points per contest going into Week 15, have seen the total go over in their last two home games.

Writer’s Prediction

The Colts win, 26-22.

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