Indianapolis Colts vs Buffalo Bills Predictions, Picks, Odds, and Betting Preview | NFL Week 11 – November 21, 2021

The Indianapolis Colts will try to go over .500 this coming Sunday, as they take on the rejuvenated Buffalo Bills in a battle between two AFC title contenders. Check out our preview of this game below.

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Betting Preview for the Indianapolis Colts vs Buffalo Bills Regular Season Week 11 Game on November 21, 2021

Where: Highmark Stadium, Orchard Park

When: Sunday, November 21, 2021, 1:00 PM ET

Line: Indianapolis Colts (+7) vs Buffalo Bills (-7) – view all 2021 NFL lines

TV Broadcast: CBS

Betting on the Indianapolis Colts (+7)

Regular Season Record: 5-5

The Colts were expected by many to take care of business in Week 10 against the Jacksonville Jaguars and Frank Reich’s team did just that, as Indianapolis defeated the Jags at home last Sunday, 23-17. Indianapolis, however, failed to cover the spread in the Jags game. Nevertheless, the Colts still look good with a record of 5-2 against the spread in their last seven games. Carson Wentz passed for 180 yards on 22/34 completions without a touchdown or an interception, while running back Jonathan Taylor dominated anew. Taylor rushed for 116 yards and a touchdown on 21 carries. Of course, the Bills are going to be a bigger challenge for the Colts, but with Wentz playing better of late and Taylor in the backfield, Indianapolis has lots of reasons to believe it can take down Buffalo on the road. Taylor can put up a Derrick Henry-esque performance in Week 11 against Buffalo’s defense that recently let the Tennessee Titans running back go off for 140+ rushing yards and three rushing scores.

Betting on the Buffalo Bills (-7)

Regular Season Record: 6-3

The Bills rebounded from a humiliating loss to the Jags in Week 9 and absolutely thrashed the New York Jets on the road in last Sunday’s 45-7 win. Josh Allen racked up 366 passing yards and a couple of touchdowns against an interception on 21/28 completions, but Buffalo also resorted to other avenues to get points. Devin Singletary, Matt Breida, Isaiah McKenzie, and Zack Moss each scored a rushing touchdown, with Breida adding a receiving touchdown as well. Meanwhile, Buffalo’s defense did not show mercy on the Jets. The Bills intercepted Jets quarterback Mike White four times, forcing five turnovers in total. Sure, that dominant performance was just against the Jets, but Buffalo is one of the few teams in the NFL today that is truly capable of pulling off that kind of excellence on both ends of the field in the same game.

The Bills are 5-4-1 against the spread in their last 10 games overall.

Writer’s Prediction

The Bills win, 27-22.

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