Los Angeles Rams vs Indianapolis Colts Predictions, Picks, Odds, and Betting Preview | NFL Week 2 – September 19, 2021

The Los Angeles Rams will pay the Indianapolis Colts a visit this Sunday for an interesting showdown between two teams with shiny new quarterbacks. Will the Rams go 2-0? Or will the Colts finally get a win? Check out our preview of this game below.

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Betting Preview for the Los Angeles Rams vs Indianapolis Colts Regular Season Week 2 Game on September 19, 2021

Where: Lucas Oil Stadium, Indianapolis

When: Sunday, September 19, 2021, 1:00 PM ET

Line: Los Angeles Rams (-4) vs Indianapolis Colts (+4) – view all 2021 NFL lines

TV Broadcast: FOX

Betting on the Los Angeles Rams (-4)

Regular Season Record: 1-0

The Matthew Stafford era in La La Land jas taken off nicely for the Rams. Surrounded by better weapons and under more competent coaching than the ones he worked with in Detroit, Stafford showed there’s so much gas left in his tank during Los Angeles’ 34-14 home win over the Chicago Bears in Week 1. Stafford passed for 321 yards and three touchdowns on 20/26 completions, without getting picked.  The passing attack is flying for the Rams, and with the likes of Cooper Kupp, Van Jefferson,  Robert Woods, and Tyler Higbee, Stafford could potentially make insane big plays again opposite the Colts’ pass defense that allowed the Seattle Seahawks to average 14.1 yards per reception. But the Rams’ defense could also play well enough to lead the way for the team. Los Angeles sacked Bears quarterbacks three times and did not allow a passing touchdown as well. Aaron Donald should be salivating right now over the prospect of facing the Colts’ offensive line that struggled a lot in Week 1.

The Rams are 3-1 against the spread in their last four games overall.

Betting on the Indianapolis Colts (+4)

Regular Season Record: 0-1

Unlike Stafford, Carson Wentz did not have a good time in his first start with his new team. Wentz did record 251 passing yards and two touchdowns without an interception on 25/38 completions, but he got sacked three times for a loss of 28 yards and was hit 10 times in a 28-16 home loss in Week 1. He was supposed to be better protected by Indianapolis’ offensive line, but here he is probably thinking whether that’s true. There’s still plenty of time to adjust for the Colts’ pass protection unit, and the game against the Rams will be a huge test for them. It was still nice to see Wentz connect with Zach Pascal for two touchdowns and have a seemingly good rapport with his running backs, even on passing plays. In fact, Jonathan Taylor and Nyheim Hines were the team’s top two receivers in Week 1. Taylor is a promising weapon for the Colts against the Rams, who gave up two rushing scores against the Bears. Sure, the Rams have Donald, but the Colts got a beast on the defensive line too in the form of DeForest Buckner, who had one of the Colts’ three sacks in Week 1.

The under is 3-0 in the Colts’ last three home games.

Writer’s Prediction

The Rams win, 23-20.

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