San Francisco 49ers vs Denver Broncos Predictions, Picks, Odds, and Betting Preview | NFL Week 3 – September 25, 2022

Russell Wilson faces off with a familiar foe as the Denver Broncos host the San Francisco 49ers in Mile High City in Week 3. Check out our preview of this 49ers vs Broncos game in Week 3 of the 2022 NFL regular season.

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Betting Preview for the San Francisco 49ers vs Denver Broncos Week 3 Game on September 25, 2022

Where: Empower Field at Mile High, Denver, Colorado

When: Sunday, September 25, 2022, 8:20 PM ET

Line: San Francisco 49ers (-2) vs Denver Broncos (+2) – view all 2022 NFL lines

TV Broadcast: NFL Network

Betting on the San Francisco 49ers (-2)

Regular Season Record: 0-2

Trey Lance is now on the injured reserve which means that the Niners will go back to starting Jimmy Garoppolo as their starter, beginning this Sunday against Denver. Jimmy G took over the 49ers’ offense in Week 2 after Lance got hurt and went 13/21 for 154 passing yards (1 touchdown, 0 INT) and also rushed for a touchdown to lead his team to a 27-7 home win over the Seattle Seahawks. Tight end George Kittle missed the Seattle game with a groin issue, but he could return just in time to face the Broncos, who have struggled against teams not expected to make the playoffs.

The 49ers are 4-0 against the spread in their last 4 games after failing to cover in the previous outing.

Betting on the Denver Broncos (+2)

Regular Season Record: 1-1

After an embarrassing Week 1 loss to Geno Smith and the Seahawks, the Broncos finally got their first win of the Russell Wilson era, as they took down the Houston Texans in week 2 at home, 16-9. However, the Broncos are yet to put together a performance worthy of the high expectations of them heading back in the preseason. They have a chance to send a big statement with the 49ers coming to town. Th Broncos two-headed rushing attack of Javonte Williams and Melvin Gordon III and Wilson’s dual-threat capabilities should put immense pressure on San Francisco’s defense that hasn’t dealt with an offense as stacked as that of Denver this season to date.

The Under is 6-0 in the Broncos’ last six games in September.

Writer’s Prediction

The Broncos win, 23-20.

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