Los Angeles Rams vs San Francisco 49ers Predictions, Picks, Odds, and Betting Preview | NFL Week 10 – November 15, 2021

The Los Angeles Rams are still trailing the Arizona Cardinals for the leadership in the NFC West. Meanwhile, the San Francisco 49ers are behind everyone in that division. Will the Rams rebound from a loss? Or will the 49ers upset LA at home? Check out our preview of this game below.

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Betting Preview for the Los Angeles Rams vs San Francisco 49ers Regular Season Week 10 Game on November 15, 2021

Where: Levi’s Stadium, Santa Clara

When: Monday, November 15, 2021, 8:15 PM ET

Line: Los Angeles Rams (-4) vs San Francisco 49ers (+4) – view all 2021 NFL lines

TV Broadcast: ESPN

Betting on the Los Angeles Rams (-4)

Regular Season Record: 7-2

The Rams got tripped up by the Tennessee Titans in a 28-16 loss to Mike Vrabel’ssquad at home in Week 9. Matthew Stafford was not at his best against the Titans, though he still managed to compile a total of 294 passing yards and a touchdown with two interceptions on 31/48 completions. Los Angeles remains a lethal offensive team despite their mediocre showing in the Titans game. Stafford is a tier 1 QB this season and he’s surrounded by elite talent downfield in the likes of Cooper Kupp and Robert Woods. Van Jefferson is a solid option as well, while Tyler Higbee is a serviceable tight end with an upside every week. The Rams are the fifth-highest scoring team in the NFL right now, as they are averaging 29.0 points per game. They are also fourth with 399.3 total yards per contest. Darrel Henderson and the Rams’ rushing attack can find holes on San Francisco’s run defense that is only 26th in the league.

The Rams are 12-3-1 against the spread in their last 16 games after a loss.

Betting on the San Francisco 49ers (+4)

Regular Season Record: 3-5

The 49ers wasted an opportunity to score a win in Week 9 against the banged-up Arizona Cardinals, who didn’t have DeAndre Hopkins and Kyler Murray, and also saw top running back Chase Edmonds exit the game with an injury. Instead, San Francisco suffered a 31-18 home loss to push them further back from the playoff picture. Nevertheless, Jimmy Garoppolo came up huge with 326 passing yards and two touchdowns with an interception on 28/40 completions. Tight end George Kittle erupted for 101 receiving yards and a touchdown on just six catches and eight targets. Garoppolo and Kittle can continue to work their magic as a pair against the Rams’ defense that is letting opponents complete 67.71% of their passes — good for only 23rd in the league. Defensively, the 49ers’ pass rush will be looking to wreak havoc in the Rams’ backfield after LA allowed five sacks to the Titans.

The 49ers are 5-2 ATS in their last seven games as a home underdog.

Writer’s Prediction

The Rams win, 28-17.

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