San Francisco 49ers vs Arizona Cardinals Predictions, Picks, Odds, and Betting Preview | NFL Week 16 – December 26, 2020

The San Francisco 49ers are out of playoff contention, but don’t expect them to take their foot off the gas pedal against the Arizona Cardinals, whom they can take to an early vacation with them. The Cardinals are still in the playoff picture, but a loss could put them on shaky ground., Check out our preview of this game below.

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Betting Preview for the San Francisco 49ers vs Arizona Cardinals Regular Season Week 16 Game on December 26, 2020

Where: State Farm Stadium, Glendale

When: Saturday, December 26, 2020, 4:30 PM ET

Line: San Francisco 49ers (+4.5) vs Arizona Cardinals (-4.5) – view all 2020 NFL lines

TV Broadcast: Amazon

Betting on the San Francisco 49ers (+4.5)

Regular Season Record: 5-9

The 49ers suffered their third loss in a row last Sunday at home and at the hands of the Dallas Cowboys, to the tune of a 41-33 score. It’s a tough loss against a bitter rival, but that’s just the story of the year for San Francisco, which is not going to make it to the playoffs. Nick Mullens passed for 219 yards and two touchdowns and two interceptions on 21-of-36 completions , while Raheem Mostert had 68 rushing yards on 14 carries. If anything,  Niners rookie wide receiver Brandon Aiyuk is having a solid stretch towards the end of the season. Aiyuk has 287 receiving yards and two touchdowns on 19 receptions over his last three games. Mostert had a big game in Week 1’s 24-20 home loss to the Cardinals when he had 56 rushing yards and 95 receiving yards.

The 49ers are 6-4 against the spread in their last 10 road games.

Betting on the Arizona Cardinals (-4.5)

Regular Season Record: 8-6

Kyler Murray led the Cardinals to an important win last Sunday over the Philadelphia Eagles at home, 33-26. Murray went 27 of 36 for 406 yards and three touchdowns with an interception and also rushed for 29 yards and a touchdown on eight carries. Murray struggled a bit in passing the ball in Week 1’s win over San Francisco, but with the Niners’ defense missing key players this time around and with the Cards’ QB riding a wave of momentum into Week 16, he could be in line for another huge game on Sunday. Meanwhile, wide receiver DeAndre Hopkins is looking forward to dominating the 49ers again. He had 151 receiving yards on 14 catches and 16 targets in Week 1. Last Sunday against the Eagles, he recorded 169 receiving yards and a touchdown on nine receptions and 11 targets. Arizona can also take advantage of San Francisco’s poor ball security. The 49ers are averaging 2.1 turnovers per game, second-highest in the NFL.

The over is 3-2 in the 49ers’ last five games at home.

Writer’s Prediction

The 49ers win, 27-24.

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