San Francisco 49ers vs Los Angeles Rams Predictions, Picks, Odds, and Betting Preview | NFL Week 12 – November 29, 2020

The Los Angeles Rams are on top of the NFC West and will look to add to their division lead when they take on the San Francisco 49ers, who are on a free fall. Will the Rams win their third game in a row? Or will the Niners trip LA up?

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Betting Preview for the San Francisco 49ers vs Los Angeles Rams Regular Season Week 12 Game on November 29, 2020

Where: SoFi Stadium, Inglewood

When: Sunday, November 29, 2020, 4:05 PM ET

Line: San Francisco 49ers (+6.5) vs Los Angeles Rams (-6.5) – view all 2020 NFL lines

TV Broadcast: FOX

Betting on the San Francisco 49ers (+6.5)

Regular Season Record: 4-6

Forget about the 49ers team that defeated the Rams in Santa Clara back in Week 6 because that team was healthier and more complete. The 49ers unit that’ll be playing in Week 12 won’t have Jimmy Garropolo, Raheem Mostert, and George Kittle among others who led San Francisco in that 24-16 home win over LA. Instead, the 49ers, this time around, will be led by quarterback Nick Mullens under center, Jerick McKinnon on the ground attack, and Brandon Aiyuk downfield. Mullens passed for 247 yards and a touchdown with two interceptions on 24-of-38 completions in the 49ers’ 27-13 home loss to the New Orleans Saints in Week 11. If anything, the 49ers held the Saints to only 3.8 rushing yards per carry, so that’s one good thing for them to take heading into a game against the Rams, who are ninth in the league with 124.5 rushing yards per game.

The 49ers are 6-4 against the spread in their last 10 road games.

Betting on the Los Angeles Rams (-6.5)

Regular Season Record: 6-3

It’s the perfect time for the Rams to try to avenge their loss to the 49ers earlier this season. The Rams have already exacted a measure of revenge on Tom Brady last Monday, when they beat the Tampa Bay Buccaneers on the road, 27-24. The Rams’ defense clobbered Tampa Bay, as they intercepted Brady twice and limited the Bucs to just 42 rushing yards. With the 49ers missing plenty of their top players on offense, the Rams are primed to eat Mullens and company alive. The Rams are allowing just 19.2 points and 291.9 yards per game, No. 2 and No. 1 in the NFL so far this season, respectively. But the Rams can also just choose to win with their offense, as San Francisco’s stop unit is also banged up. The 49ers have allowed 32.7 points in their last three games, which is second-worst in the league over that stretch.

The Rams are 3-1-1 against the spread in their last five home games.

Writer’s Prediction

The Rams win, 34-17.

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