Seattle Seahawks vs San Francisco 49ers Predictions, Picks, Odds, and Betting Preview | NFL Week 4 – October 3, 2021

The Seattle Seahawks and the San Francisco 49ers meet head-on this coming weekend at Levi’s Stadium in an interesting all-NFC West battle. Check out our preview of this game below along with our prediction for the winner and final score.

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Betting Preview for the Seattle Seahawks vs San Francisco 49ers Regular Season Week 4 Game on October 3, 2021

Where: Levi’s Stadium, Santa Clara

When: Sunday, October 3, 2021, 4:05 PM ET

Line: Seattle Seahawks (+2.5) vs San Francisco 49ers (-2.5) – view all 2021 NFL lines

TV Broadcast: FOX

Betting on the Seattle Seahawks (+2.5)

Regular Season Record: 1-2

Seattle’s back is against the wall right now after suffering two losses in a row. The Seahawks are coming off a 30-17 road loss to the Minnesota Vikings a week after losing to the Tennessee Titans at home, 33-30.  The defense is clearly a problem for Seattle, but the story for the Seahawks has always been as long as they have Russell Wilson, they are in a position to win any game. Seattle’s offense is averaging 25.0 points per game on the strength of a passing attack that’s currently 10th in the NFL with 281.3 passing yards per game. Wilson is airing it out big time from the pocket, as the Seahawks are tops in the league with 9.8 yards per pass, and that’s also credit to his targets. DK Metcalf and Tyler Lockett are a problem for opposing defensive backs, while running back Chris Carson also stands to be a big contributor against San Francisco, which is allowing over 120 rushing yards per game.

The Seahawks are 4-1 against the spread in their last five Week 4 games.

Betting on the San Francisco 49ers (-2.5)

Regular Season Record: 2-1

There’s no shame in losing to Aaron Rodgers, but the 49ers’ 30-28 home loss to the Green Bay Packers over the weekend was a painful one for the Niners, who will look to rebound with a win this coming Sunday. In that game, Jimmy Garoppolo looked shaky again, as he went 25 /40 for 257 passing yards, two touchdowns, and an interception. The 49ers are pretty thin in the backfield with all the injuries to their running backs, but they can still capitalize on Seattle’s atrocious defense, particularly against the pass. The Seahawks are allowing 155.0 rushing yards per game, so far this season. They have been wrecked hard in the last two games by the Titans’ Derrick Williams and Vikings’ Alex Mattison. Trey Sermon isn’t an elite running back just yet, but he’s got the potential to dominate Seattle, especially if Garoppolo opens up the field with his receivers.

The 49ers are 4-1 against the spread in their last five games in Week 4.

Writer’s Prediction

The Seahawks win, 28-26.

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