Colts vs Titans Predictions, Picks, Odds

The Indianapolis Colts are still winless and currently sharing the bottom spot of the AFC South with the Jacksonville Jaguars. Meanwhile, the Tennessee Titans are now in the win column and will shoot for win No. 2 this coming weekend at home against the visiting Colts. Check out our preview of this game below.

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Betting Preview for the Indianapolis Colts vs Tennessee Titans Regular Season Week 3 Game on September 26, 2021

Where: Nissan Stadium, Nashville

When: Sunday, September 26, 2021, 1:00 PM ET

Line: Indianapolis Colts (+5) vs Tennessee Titans (-5) – view all 2021 NFL lines

TV Broadcast: CBS

Betting on the Indianapolis Colts (+5)

Regular Season Record: 0-2

The Colts are 0-2 to start the season for the first time since Frank Reich took over as the team’s head coach. That’s after they absorbed a 27-24 home loss at the hands of the Los Angeles Rams last Sunday. Carson Wentz passed for 347 yards and a touchdown and interception on 20/32 completions. Wentz also suffered an ankle injury that may keep him out of the Tennessee game. This is obviously not a good start for Indianapolis, which will come to Tennessee with a great sense of urgency to win. One of the keys for Indianapolis in Week 3 will be the sturdiness of its pass protection that has allowed six sacks. If Wentz can’t go, the Colts will give the ball to Jacob Eason, which would put even more pressure on the Colts’ offensive line that used to be one of the best in the NFL. This could also mean more chances for Jonathan Taylor to run the ball. Taylor only has 107 rushing yards on 32 carries so far this season.

The Colts are 2-1 against the spread in their last three games overall.

Betting on the Tennessee Titans (-5)

Regular Season Record: 1-1

Tennessee finally scored a win in the 2021 NFL season. The Titans recovered from a 38-13 beating at the hands of the Arizona Cardinals at home in Week 1 by scoring a 33-30 overtime victory over the Seattle Seahawks in Week 2. It was a game where Julio Jones broke out for his new team. Jones was silent in the Arizona game but exploded for 128 receiving yards on just six carries. Also, running back Derrick Henry smashed through Seattle’s defense for 182 rushing yards and three touchdowns on 35 carries. The defense still needs some fixing for Tennessee, but given Indianapolis’ quarterback status, the Titans could effectively limit a Colts’ offense that might have Eason under center. Tennessee’s defense is staring at the Colts’ leaky pass protection that’s a favorable matchup for the Titans’ defensive front.

The Titans are 5-5 against the spread in their last 10 games overall.