49ers vs Giants Predictions, Picks, Odds, Preview

The San Francisco 49ers are ravaged by injuries, but they have no choice but to go to work in Week 3 against the winless New York Giants. Will the 49ers score a victory despite their banged-up roster? Or will the Saquon Barkley-less Giants finally get their first win of the season?

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Betting Preview for the San Francisco 49ers vs New York Giants Regular Season Week 3 Game on September 27, 2020

Where: MetLife Stadium, East Rutherford

When: Sunday, September 27, 2020, 1:00 PM ET

Line: San Francisco 49ers (-4) vs New York Giants (+4) – view all 2020 NFL lines

TV Broadcast: FOX

Betting on the San Francisco 49ers (-4)

Regular Season Record: 1-1

The 49ers’ roster looked like an infirmary right now, with all the hurt bodies on the shelf. Although the 49ers earned a 31-13 win road win against the New York Jets last Sunday, it was more of a Phyrric Victory, as they saw star defensive end Nick Bosa and quarterback Jimmy Garoppolo go down with injuries. Bosa is feared to be done for the season after tearing his ACL while Garoppolo is currently considered week-to-week due to an ankle issue. If Garoppolo can’t go, the 49ers will be forced to hand the ball to backup Nick Mullens, who went 8-of-11 for 71 passing yards (0 touchdowns, 1 interception) against the Jets. Running back Raheem Mostert might not also be available to play in Week 3 because of a mild MCL sprain. Jerick McKinnon, who rushed for 77 yards on just three carries against the Jets stand to get an increased workload if Mostert misses time. If anything, the Giants does not look like a team that would require the best players of the 49ers to be available to beat them.

The 49ers are 5-2 against the spread in their last seven games overall.

Betting on the New York Giants (+4)

Regular Season Record: 0-2

The Giants have an injury to deal with, and it’s of their best player. Running back Saquon Barkley tore his ACL in last Sunday’s 17-13 road loss to the Chicago Bears. Losing Barkley for an entire season is a huge blow to the Giants, whose offense is largely dependent on the tailback. That’s despite the fact that they are only averaging 52.0 rushing yards per game. The problem for the Giants is their ineffective offensive line that couldn’t give holes for New York’s rushersd to burst through. Without Barkley, Daniel Jones and the Giants’ passing game will be even more featured. Jones is off to shaky start this season, as he’s collected 520 passing yards and two touchdowns against three interceptions in two games. He’s also been sacked seven times already. At full strength, the 49ers’ defense would likely maul Jones in the pocket, but without Bosa and Dee Ford possibly out for Week 3 plus the fact that cornerback Richard Sherman is on the injured reserve list, there should be enough breathing space for Jones to find his top targets in Darius Slayton, Golden Tate, and Evan Engram.

The over is 4-1 in the Giants’ last five home games.