The San Francisco 49ers are getting more and more comfortable with Christian McCaffrey in the fold. They won 22-16 over the Los Angeles Chargers last Sunday. The Arizona Cardinals, on the other hand, are back in the win column after defeating the Los Angeles Rams in Week 10 on the road, 27-17, despite missing quarterback Kyler Murray. Check out our preview of this 49ers vs Cardinals game in Week 11 of the 2022 NFL regular season.
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Betting Preview for the San Francisco 49ers vs Arizona Cardinals Week 11 Game on November 20, 2022
Where: Estadio Azteca, Mexico City, MX
When: Sunday, November 20, 2022, 8:15 PM ET
Line: San Francisco 49ers (-8.0) vs Arizona Cardinals (+8.0) – view all 2022 NFL lines
TV Broadcast: ESPN
Betting on the San Francisco 49ers (-8.0)
Regular Season Record: 5-4
The 49ers have so many terrific weapons that they look capable of surviving poor performances from Jimmy Garoppol0. Jimmy G was solid in driving the offense down the field, though, in Week 10, passing for 240 yards with zero interceptions on 19/28 completions. The combo of Elijah Mitchell and Christian McCaffrey in the backfield is going to spell trouble for Arizona, while Brandon Aiyuk, Deebo Samuel, and George Kittle will give an entirely different problem for the Cardinals’ defense that is third-worst in the NFL with 25.8 points allowed per game.
The 49ers are 5-0 against the spread in their last five games against NFC West teams.
Betting on the Arizona Cardinals (+8.0)
Regular Season Record: 4-6
It’s still not clear whether Kyler Murray will be ready to play in Week 11 after missing last Sunday’s game against the Rams. In any case, the Cardinals feel good about their chances even if it’s going to be Colt McCoy under center for them versus the Niners. McCoy was effective in the Rams game, passing for 238 yards and a touchdown with zero interceptions while going 26/37. DeAndre Hopkins and Rondale Moore are starting to look – if they haven’t yet – a huge 1-2 threat downfield. They combined for 192 receiving yards on 19 catches in Week 10 for the Cardinals, who don’t turn the ball over a lot, as evidenced by their average of a mere 0.9 giveaways per game.
The Over is 4-0 in the Cardinals’ last four games overall.
Writer’s Prediction
The Cardinals win, 24-20.
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